1. GPCR cell line development
GPCRs are the most common target for novel drug discovery. Developing GPCR cell lines is time consuming and proper folding and localization is very important. With very experience hands we provide you a large product range covering GPCR cell lines, as well as well other products made using these stable cell lines upon your specifications. Our services include cloning of the transgene, transfection of target cell lines, screening of clonal selected stable cells, expansion of clones with best expression, providing client with 3 frozen vials of best expressing clones.
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2. Nuclear receptors
Nuclear receptors (NRs) are now becoming ideal targets for drug discovery. Not only do they control a heap of biological and disease processes, but they are also regulated by small molecules that can be easily exchanged with a drug of choice. We provide wide range of choices in multiple nuclear receptors systems for the development of their stable cell line. Our services include cloning of the transgene, transfection of target cell lines, screening of clonal selected stable cells, expansion of clones with best expression, providing client with 3 frozen vials of best expressing clones.
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Transcription factors: Transcription factors play a major role in regulation of gene expression; they can act as both transcriptional activators and repressors in response to a signaling pathway. We can help you in developing reporters cell lines with luciferase activity as a assay read out. Our services include cloning of the transgene, cloning of the luciferase gene under the control of transcriptional response element, transfection of target cell lines, screening of clonal selected stable cells, expansion of clones with best expression, providing client with 3 frozen vials of best expressing clones.
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