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Global Protein Expression Array

Global Protein Expression Array format is a well established array for the rapid, global analysis of proteins as in the use of oligonucleotides and cDNA array for gene expression profiling. However, mRNA expression data has acknowledged shortcomings as an indicator of actual protein abundance or dynamics, and moreover reveals nothing about post-translational modifications or protein-protein interactions. Two-dimensional gel electrophoresis technology, on which most proteome profiling is based currently, is also limited in various ways, particularly in the difficulty of finding and quantitatively estimating low abundance proteins. For information about the expression of the proteome, protein and peptide arrays are becoming major tools and the information that will be obtained from them in the future will complement transcriptional data.



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Global Protein Array



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