Biomolecular interactions score a vital role in almost every development in a living cell. Conformational changes, reversible associations, and assembly of macromolecular complexes have essential responsibilities in biological organisms and are the ultimate target to learn in understanding the strength of interactions and determining the consequences of the interaction. Studying protein: protein interactions and the degree of regulation they confer, helps improving our understanding of the diseases and scheming new therapeutic approaches. And this determination is only the first step in understanding if, and to what extent, the interaction takes place in vivo.
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